| Southern Illinois Salukis Football vs. Thomas More Saints | 8-30-2025
Saturday
TBD | Saluki Stadium in Carbondale, IL | View Tickets |
| Purdue Boilermakers Football vs. Southern Illinois Salukis | 9-6-2025
Saturday
TBD | Ross-ade Stadium in West Lafayette, IN | View Tickets |
| UT Martin Skyhawks Football vs. Southern Illinois Salukis | 9-13-2025
Saturday
TBD | Hardy Graham Stadium in Martin, TN | View Tickets |
| Southeast Missouri Redhawks Football vs. Southern Illinois Salukis | 9-20-2025
Saturday
TBD | Houck Stadium in Cape Girardeau, MO | View Tickets |
| Southern Illinois Salukis Football vs. Indiana State Sycamores | 10-4-2025
Saturday
TBD | Saluki Stadium in Carbondale, IL | View Tickets |
| North Dakota State Bison Football vs. Southern Illinois Salukis | 10-11-2025
Saturday
TBD | Fargodome in Fargo, ND | View Tickets |
| Southern Illinois Salukis Football vs. North Dakota Fighting Hawks | 10-18-2025
Saturday
TBD | Saluki Stadium in Carbondale, IL | View Tickets |
| Southern Illinois Salukis Football vs. Northern Iowa Panthers | 10-25-2025
Saturday
TBD | Saluki Stadium in Carbondale, IL | View Tickets |
| Murray State Racers Football vs. Southern Illinois Salukis Football | 11-1-2025
Saturday
TBD | Roy Stewart Stadium in Murray, KY | View Tickets |
| Youngstown State Penguins Football vs. Southern Illinois Salukis | 11-8-2025
Saturday
TBD | Stambaugh Stadium in Youngstown, OH | View Tickets |
| Southern Illinois Salukis Football vs. South Dakota Coyotes | 11-15-2025
Saturday
TBD | Saluki Stadium in Carbondale, IL | View Tickets |
| Illinois State Redbirds Football vs. Southern Illinois Salukis | 11-22-2025
Saturday
TBD | Hancock Stadium in Normal, IL | View Tickets |
